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Oct 29, 2021 · RNA Pol III is responsible for converting AT-rich DNA into RNA PAMP to trigger proper IFN-I production during VZV infection through an unrevealed RNA-sensing mechanism.
Oct 7, 2021 · In this review, we focus on various host sensing molecules and discuss the associated signaling pathways that are activated in response to different viral infections. We …
Mar 20, 2015 · One of the target genes, exportin-1, is shown to regulate cytosolic RNA:DNA hybrids. Taken together, we reveal previously unknown mechanism by which Pol III regulates …
Oct 10, 2018 · Nuclear POL III transcribes 5S RNA, while cytoplasmic POL III transcribes AT-rich DNA into an RNA form that activates the immune receptor RIG-I. Heterozygous mutations in …
Here we identify a novel DNA-sensing pathway involving RNA polymerase III and RIG-I. In this pathway, AT-rich double-stranded DNA (dsDNA) served as a template for RNA polymerase...
Jun 1, 2023 · A growing literature demonstrates that mammalian RNA polymerase III (Pol III) transcribes certain viral or cellular DNA sequences into immunostimulatory RIG-I ligands, …
Here, we reveal that the EBV immediate-early protein BRLF1 inhibits RIG-I inflammasome activation and antiviral responses via RNA polymerase III during the early stages of primary …
Apr 9, 2024 · Ribosomal RNA (rRNA) and transfer RNA (tRNA) are the major cellular RNA synthesized by RNA Pol I and RNA Pol III. These housekeeping RNAs are transcribed in the …
Aug 7, 2009 · In this report, we show that the double-stranded DNA (dsDNA) poly (dA-dT)•poly (dA-dT), herein referred to as poly (dA-dT), is converted to an RNA species in the cytosol to …
成長している文献は,哺乳類RNAポリメラーゼIII (Pol III)が,抗ウイルスまたは炎症反応を誘発する免疫刺激RIG-Iリガンドにある種のウイルスまたは細胞DNA配列を転写することを示す。
Jun 1, 2023 · A growing literature demonstrates that mammalian RNA polymerase III (Pol III) transcribes certain viral or cellular DNA sequences into immunostimulatory RIG-I ligands, …
RNA Pol IIIにより転写される遺伝子は「ハウスキーピング」遺伝子に分類され、全ての細胞種とほとんどの環境条件において、これらの遺伝子の発現が必須である。
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